Ordering Panhematin

Ordering Panhematin

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How to order PANHEMATIN

Order through Canadian Blood Services and Héma‑Québec

How supplied

PANHEMATIN is supplied as a sterile, lyophilized black powder in single dose dispensing vials in a carton.

The vial stopper contains natural rubber latex.

Store lyophilized powder at 20-25°C (68-77°F).

Hemin for injection. PANHEMATIN.

About PANHEMATIN for Treatment of AIP

PANHEMATIN (hemin for injection) is an enzyme inhibitor derived from processed red blood cells and is indicated for the amelioration of recurrent attacks of acute intermittent porphyria temporally related to the menstrual cycle in susceptible women, after initial carbohydrate therapy is known or suspected to be inadequate.

How does PANHEMATIN work?

The exact mechanism by which hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been elucidated.1,‡

  • Heme acts to limit the hepatic and/or marrow synthesis of porphyrin. This action is likely due to the inhibition of δ-aminolevulinic acid synthase, the enzyme which limits the rate of the porphyrin/heme biosynthetic pathway
  • PANHEMATIN therapy is intended to limit the rate of porphyria/heme biosynthesis possibly by inhibiting ALA synthase, which is the first enzyme in the heme biosynthetic pathway

† Clinical significance unknown.

‡ PANHEMATIN is only indicated for the amelioration of recurrent attacks of acute intermittent porphyria temporally related to the menstrual cycle in susceptible women, after initial carbohydrate therapy is known or suspected to be inadequate.


Reference

  1. Recordati Rare Diseases Canada Inc. PANHEMATIN® Product Monograph. July 13, 2018.